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Pregnancy and breastfeeding are also contraindications due to insufficient safety data

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Safety and efficacy of GLP-1 receptor agonists in type 2 diabetes mellitus with advanced and end-stage kidney disease: A systematic review and meta-analysis

Figure 3 provides an integrative schematic distinguishing the indirect systemic metabolic benefits of GLP-1RAs from their direct epithelial reparative programs, highlighting where confounding by weight loss is unavoidable versus where true mucosal repair mechanisms are expected to dominate